Conventional type I dendritic cells maintain a reservoir of proliferative tumor-antigen specific TCF-1<sup>+</sup> CD8<sup>+</sup> T cells in tumor-draining lymph nodes.

导出 OA

翻译打印收藏纠错

作者： Jason M,Schenkel ^[1] ; Rebecca H,Herbst ^[2] ; David,Canner ^[3] ; Amy,Li ^[4] ; Michelle,Hillman ^[5] ; Sean-Luc,Shanahan ^[5] ; Grace,Gibbons ^[5] ; Olivia C,Smith ^[5] ; Jonathan Y,Kim ^[5] ; Peter,Westcott ^[5] ; William L,Hwang ^[6] ; William A,Freed-Pastor ^[7] ; George,Eng ^[8] ; Michael S,Cuoco ^[9] ; Patricia,Rogers ^[9] ; Jin K,Park ^[10] ; Megan L,Burger ^[5] ; Orit,Rozenblatt-Rosen ^[9] ; Le,Cong ^[11] ; Kristen E,Pauken ^[12] ; Aviv,Regev ^[13] ; Tyler,Jacks ^[14]

作者单位： David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA. ^[1] Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA. ^[2] David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. ^[3] David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. ^[4] David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA. ^[5] David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA; Department of Radiation Oncology, Massachusetts General Hospital, Boston MA 02114. ^[6] David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. ^[7] David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA. ^[8] Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA. ^[9] David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA. ^[10] Departments of Pathology, Stanford University, Stanford, CA 94305, USA. ^[11] Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA. ^[12] David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address: aviv.regev.sc@gmail.com. ^[13] David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address: tjacks@mit.edu. ^[14]

关键词 CD8 T cells Flt3L T cell dysfunction TCF-1+anti-CD40 migratory cDC1 single-cell RNA-seq tumor immunology tumor-draining lymph node