首页> Kidney international> Kidney toxicity of the BRAF-kinase inhibitor vemurafenib is driven by off-target ferrochelatase inhibition.

Kidney toxicity of the BRAF-kinase inhibitor vemurafenib is driven by off-target ferrochelatase inhibition.

导出 OA

翻译打印收藏纠错

第一作者： Yuntao,Bai

第一单位： Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.

作者： Yuntao,Bai ^[1] ; Ji Young,Kim ^[1] ; Bijay,Bisunke ^[2] ; Laura A,Jayne ^[1] ; Josie A,Silvaroli ^[1] ; Michael S,Balzer ^[3] ; Megha,Gandhi ^[1] ; Kevin M,Huang ^[1] ; Veronika,Sander ^[4] ; Jason,Prosek ^[5] ; Rachel E,Cianciolo ^[6] ; Sharyn D,Baker ^[1] ; Alex,Sparreboom ^[1] ; Kenar D,Jhaveri ^[7] ; Katalin,Susztak ^[3] ; Amandeep,Bajwa ^[8] ; Navjot Singh,Pabla ^[9]

作者单位： Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA. ^[1] Department of Genetics, Genomics, and Informatics, College of Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee, USA. ^[2] Department of Medicine and Genetics, Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, Pennsylvania, USA. ^[3] Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand. ^[4] Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA. ^[5] Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA. ^[6] Division of Kidney Diseases and Hypertension, Donald and Barbara Zucker School of Medicine at Hofstra-Northwell, Northwell Health, Great Neck, New York, USA. ^[7] Department of Genetics, Genomics, and Informatics, College of Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee, USA; Department of Microbiology, Immunology, and Biochemistry, College of Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee, USA; Transplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, College of Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee, USA. ^[8] Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA. Electronic address: pabla.2@osu.edu. ^[9]

关键词 BRAF kinase acute kidney injury ferrochelatase onconephrology protein kinase inhibitors renal tubular epithelial cells