A cell-free nanobody engineering platform rapidly generates SARS-CoV-2 neutralizing nanobodies.

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作者： Xun,Chen ^[1] ; Matteo,Gentili ^[2] ; Nir,Hacohen ^[2] ; Aviv,Regev ^[3]

作者单位： Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. xun@broadinstitute.org. ^[1] Broad Institute of MIT and Harvard, Cambridge, MA, USA. ^[2] Department of Medicine, Harvard Medical School, Boston, MA, USA. ^[3] Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA. ^[4] Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. aviv.regev.sc@gmail.com. ^[5] Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. aviv.regev.sc@gmail.com. ^[6] Howard Hughes Medical Institute, Chevy Chase, MD, USA. aviv.regev.sc@gmail.com. ^[7] Genentech, 1 DNA Way, South San Francisco, CA, USA. aviv.regev.sc@gmail.com. ^[8]

主题词抗体, 中和(Antibodies, Neutralizing);抗体, 病毒(Antibodies, Viral);人类(Humans);蛋白质结合(Protein Binding);蛋白质工程(Protein Engineering);结果可重复性(Reproducibility of Results)

DOI 10.1038/s41467-021-25777-z

PMID 34535642

发布时间 2024-05-27

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