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Potent pro-apoptotic combination therapy is highly effective in a broad range of cancers.

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第一作者： Antonella,Montinaro

第一单位： Centre for Cell Death, Cancer, and Inflammation (CCCI), UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK.

作者： Antonella,Montinaro ^[1] ; Itziar,Areso Zubiaur ^[1] ; Julia,Saggau ^[2] ; Anna-Laura,Kretz ^[3] ; Rute M M,Ferreira ^[1] ; Omar,Hassan ^[2] ; Ella,Kitzig ^[3] ; Ines,Müller ^[4] ; Mona A,El-Bahrawy ^[5] ; Silvia,von Karstedt ^[6] ; Dagmar,Kulms ^[4] ; Gianmaria,Liccardi ^[7] ; Johannes,Lemke ^[3] ; Henning,Walczak ^[8]

作者单位： Centre for Cell Death, Cancer, and Inflammation (CCCI), UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK. ^[1] CECAD Cluster of Excellence, University of Cologne, 50931, Cologne, Germany.;Center for Biochemistry, Medical Faculty, Joseph-Stelzmann-Str. 52, University of Cologne, 50931, Cologne, Germany. ^[2] Department of General and Visceral Surgery, Ulm University Hospital, Albert-Einstein-Allee 23, 89081, Ulm, Germany. ^[3] Experimental Dermatology, Department of Dermatology, Technical University Dresden, Dresden, Germany. ^[4] Department of Histopathology, Imperial College London, London, W12 0NN, UK. ^[5] Centre for Cell Death, Cancer, and Inflammation (CCCI), UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK.;CECAD Cluster of Excellence, University of Cologne, 50931, Cologne, Germany.;Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany.;Center for Molecular Medicine Cologne, Medical Faculty, University Hospital of Cologne, 50931, Cologne, Germany. ^[6] Center for Biochemistry, Medical Faculty, Joseph-Stelzmann-Str. 52, University of Cologne, 50931, Cologne, Germany. ^[7] Centre for Cell Death, Cancer, and Inflammation (CCCI), UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK. h.walczak@ucl.ac.uk.;CECAD Cluster of Excellence, University of Cologne, 50931, Cologne, Germany. h.walczak@ucl.ac.uk.;Center for Biochemistry, Medical Faculty, Joseph-Stelzmann-Str. 52, University of Cologne, 50931, Cologne, Germany. h.walczak@ucl.ac.uk. ^[8]

医学主题词抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);细胞系, 肿瘤(Cell Line, Tumor);线粒体(Mitochondria);肿瘤(Neoplasms);TNF相关凋亡诱导配体(TNF-Related Apoptosis-Inducing Ligand)

DOI 10.1038/s41418-021-00869-x

PMID 34535764

发布时间 2025-11-20

基金项目

214342/Z/18/Z/WT_/Wellcome Trust/United Kingdom 515818/CRUK_/Cancer Research UK/United Kingdom 27323/CRUK_/Cancer Research UK/United Kingdom A27323/CRUK_/Cancer Research UK/United Kingdom MR/S00811X/1/MRC_/Medical Research Council/United Kingdom WT_/Wellcome Trust/United Kingdom

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