Inhibitory G-protein-mediated modulation of slow delayed rectifier potassium channels contributes to increased susceptibility to arrhythmogenesis in aging heart.
第一作者:
Sihao,Zou
第一单位:
Department of Pharmacology, Hebei Medical University, The Key Laboratory of New Drug Pharmacology and Toxicology, Hebei, China.
作者:
主题词
肾上腺素能β-2受体拮抗剂(Adrenergic beta-2 Receptor Antagonists);动物(Animals);抗心律失常药(Anti-Arrhythmia Agents);心律失常, 心性(Arrhythmias, Cardiac);延迟整流钾通道(Delayed Rectifier Potassium Channels);GTP结合蛋白质α亚单位, Gi-Go(GTP-Binding Protein alpha Subunits, Gi-Go);豚鼠(Guinea Pigs);HEK293细胞(HEK293 Cells);人类(Humans);异丙肾上腺素(Isoproterenol);膜电位(Membrane Potentials);肌细胞, 心脏(Myocytes, Cardiac);膜片钳术(Patch-Clamp Techniques);百白咳毒素(Pertussis Toxin)
DOI
10.1016/j.hrthm.2021.09.014
PMID
34536591
发布时间
2022-03-03
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Heart rhythm
2197-2209页
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