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Dysfunction of epithelial permeability barrier induced by HMGB1 in 2.5D cultures of human epithelial cells.

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第一作者： Takashi,Kojima

第一单位： Department of Cell Science, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.

作者： Takashi,Kojima ^[1] ; Yuma,Shindo ^[2] ; Takumi,Konno ^[1] ; Yuki,Kodera ^[3] ; Wataru,Arai ^[2] ; Maki,Miyakawa ^[4] ; Kizuku,Ohwada ^[5] ; Hiroki,Tanaka ^[6] ; Mitsuhiro,Tsujiwaki ^[7] ; Yuji,Sakuma ^[8] ; Shin,Kikuchi ^[9] ; Tsuyoshi,Ohkuni ^[10] ; Kenichi,Takano ^[10] ; Atsushi,Watanabe ^[11] ; Takayuki,Kohno ^[1]

作者单位： Department of Cell Science, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan. ^[1] Department of Cell Science, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.;Department of Thoracic Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan. ^[2] Department of Cell Science, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.;Department of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, Sapporo, Japan. ^[3] Department of Cell Science, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.;IBD Hospital, Sapporo, Japan. ^[4] Department of Cell Science, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.;Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan. ^[5] IBD Hospital, Sapporo, Japan. ^[6] Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan. ^[7] Department of Molecular Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan. ^[8] Department of Anatomy, Sapporo Medical University School of Medicine, Sapporo, Japan. ^[9] Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan. ^[10] Department of Thoracic Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan. ^[11]

关键词 2.5d matrigel cultures EW-7197 PF431396 PYK2 TGF-β angulin-1/LSR cell metabolism claudins epithelial permeability barriers hmgb1 human intestinal epithelial cell line CACO-2 normal human nasal epithelial cells normal human pulmonary epithelial cells p63 proinflammatory cytokines tight junctions tnfα-antibody tricellulin

主题词上皮细胞(Epithelial Cells);HMGB1蛋白质(HMGB1 Protein);人类(Humans);通透性(Permeability);信号传导(Signal Transduction);紧密连接部(Tight Junctions)

DOI 10.1080/21688370.2021.1972760

PMID 34538217

发布时间 2022-09-19

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Tissue barriers

2022年10卷2期

1972760页

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Dysfunction of epithelial permeability barrier induced by HMGB1 in 2.5D cultures of human epithelial cells.

Tissue barriers

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Tissue barriers

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Dysfunction of epithelial permeability barrier induced by HMGB1 in 2.5D cultures of human epithelial cells.

Tissue barriers

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Tissue barriers

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