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Multimodal electrophysiological analyses reveal that reduced synaptic excitatory neurotransmission underlies seizures in a model of NMDAR antibody-mediated encephalitis.

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第一作者： Sukhvir K,Wright

第一单位： Institute of Health and Neurodevelopment, College of Health and Life Sciences, Aston University, Birmingham, UK. s.wright5@aston.ac.uk.;Department of Paediatric Neurology, The Birmingham Women's and Children's Hospital NHS Foundation Trust, Birmingham, UK. s.wright5@aston.ac.uk.

作者： Sukhvir K,Wright ^[1] ; Richard E,Rosch ^[2] ; Max A,Wilson ^[3] ; Manoj A,Upadhya ^[3] ; Divya R,Dhangar ^[3] ; Charlie,Clarke-Bland ^[3] ; Tamara T,Wahid ^[3] ; Sumanta,Barman ^[4] ; Norbert,Goebels ^[4] ; Jakob,Kreye ^[5] ; Harald,Prüss ^[6] ; Leslie,Jacobson ^[7] ; Danielle S,Bassett ^[8] ; Angela,Vincent ^[7] ; Stuart D,Greenhill ^[3] ; Gavin L,Woodhall ^[9]

作者单位： Institute of Health and Neurodevelopment, College of Health and Life Sciences, Aston University, Birmingham, UK. s.wright5@aston.ac.uk.;Department of Paediatric Neurology, The Birmingham Women's and Children's Hospital NHS Foundation Trust, Birmingham, UK. s.wright5@aston.ac.uk. ^[1] MRC Centre for Neurodevelopmental Disorders, King's College London, London, UK. richard.rosch@kcl.ac.uk.;Department of Paediatric Neurology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK. richard.rosch@kcl.ac.uk.;Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA. richard.rosch@kcl.ac.uk. ^[2] Institute of Health and Neurodevelopment, College of Health and Life Sciences, Aston University, Birmingham, UK. ^[3] Department of Neurology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. ^[4] German Center for Neurodegenerative Diseases (DZNE) Berlin, Berlin, Germany.;Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.;Department of Pediatric Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany. ^[5] German Center for Neurodegenerative Diseases (DZNE) Berlin, Berlin, Germany.;Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany. ^[6] Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK. ^[7] Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.;Santa Fe Institute, Santa Fe, NM, USA. ^[8] Institute of Health and Neurodevelopment, College of Health and Life Sciences, Aston University, Birmingham, UK. g.l.woodhall@aston.ac.uk. ^[9]

医学主题词动物(Animals);自身抗体(Autoantibodies);疾病模型, 动物(Disease Models, Animal);男(雄)性(Male);大鼠(Rats);大鼠, Wistar(Rats, Wistar);突触传递(Synaptic Transmission)

DOI 10.1038/s42003-021-02635-8

PMID 34545200

发布时间 2025-05-30

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Communications biology

2021年4卷1期

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Communications biology

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Multimodal electrophysiological analyses reveal that reduced synaptic excitatory neurotransmission underlies seizures in a model of NMDAR antibody-mediated encephalitis.

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Multimodal electrophysiological analyses reveal that reduced synaptic excitatory neurotransmission underlies seizures in a model of NMDAR antibody-mediated encephalitis.

Communications biology

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