BthTX-II from Bothrops jararacussu venom has variants with different oligomeric assemblies: An example of snake venom phospholipases A<sub>2</sub> versatility.

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作者： Rafael J,Borges ^[1] ; Guilherme H M,Salvador ^[2] ; Henrique B,Campanelli ^[2] ; Daniel C,Pimenta ^[3] ; Mario,de Oliveira Neto ^[2] ; Isabel,Usón ^[4] ; Marcos R M,Fontes ^[5]

作者单位： Department of Biophysics and Pharmacology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, São Paulo 18618-689, Brazil; Crystallographic Methods, Institute of Molecular Biology of Barcelona - Spanish National Research Council (IBMB-CSIC), Barcelona 08028, Spain. Electronic address: rafael.borges@unesp.br. ^[1] Department of Biophysics and Pharmacology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, São Paulo 18618-689, Brazil. ^[2] Biochemistry and Biophysics Laboratory, Butantan Institute, São Paulo, São Paulo 05503-900, Brazil. ^[3] Crystallographic Methods, Institute of Molecular Biology of Barcelona - Spanish National Research Council (IBMB-CSIC), Barcelona 08028, Spain; ICREA, Institució Catalana de Recerca i Estudis Avançats, Pg. Lluís Companys 23, 08010 Barcelona, Spain. ^[4] Department of Biophysics and Pharmacology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, São Paulo 18618-689, Brazil. Electronic address: marcos.fontes@unesp.br. ^[5]

关键词 Basic phospholipase A(2)Bothrops jararacussu BthTX-II Oligomeric assembly SEQUENCE SLIDER Snake venom toxins

主题词结合部位(Binding Sites);钙(Calcium);响尾蛇毒液类(Crotalid Venoms);Ⅱ型磷脂酶A2(Group II Phospholipases A2);分子动力学模拟(Molecular Dynamics Simulation);蛋白质结合(Protein Binding);蛋白质多聚化(Protein Multimerization)

DOI 10.1016/j.ijbiomac.2021.09.083

PMID 34547312

发布时间 2021-12-16

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