Antitumor Activity of the Novel BTK Inhibitor TG-1701 Is Associated with Disruption of Ikaros Signaling in Patients with B-cell Non-Hodgkin Lymphoma.

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第一作者： Marcelo Lima,Ribeiro

第一单位： Lymphoma Translational Group, Josep Carreras Leukaemia Research Institute, Badalona, Spain.

作者： Marcelo Lima,Ribeiro ^[1] ; Diana,Reyes-Garau ^[2] ; Meritxell,Vinyoles ^[1] ; Núria,Profitós Pelejà ^[3] ; Juliana Carvalho,Santos ^[4] ; Marc,Armengol ^[5] ; Miranda,Fernández-Serrano ^[1] ; Alícia,Sedó Mor ^[1] ; Joan J,Bech-Serra ^[1] ; Pedro,Blecua ^[6] ; Eva,Musulen ^[1] ; Carolina,De La Torre ^[6] ; Hari,Miskin ^[1] ; Manel,Esteller ^[6] ; Francesc,Bosch ^[7] ; Pablo,Menéndez ^[8] ; Emmanuel,Normant ^[8] ; Gaël,Roué ^[9]

作者单位： Lymphoma Translational Group, Josep Carreras Leukaemia Research Institute, Badalona, Spain. ^[1] Laboratory of Immunopharmacology and Molecular Biology, Sao Francisco University Medical School, Braganca Paulista, São Paulo, Brazil. ^[2] Stem Cell Biology, Developmental Leukemia and Immunotherapy Group, Josep Carreras Leukaemia Research Institute, Badalona, Spain. ^[3] Department of Biomedicine, School of Medicine, University of Barcelona, Barcelona, Spain. ^[4] Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III, Barcelona, Spain. ^[5] Autonomous University of Barcelona, Barcelona, Spain. ^[6] Proteomics Unit, Josep Carreras Leukaemia Research Institute, Badalona, Spain. ^[7] Cancer Epigenetics Group, Josep Carreras Leukaemia Research Institute, Badalona, Spain. ^[8] Department of Pathology, Hospital Universitari General de Catalunya-Grupo Quironsalud, Sant Cugat del Vallès, Spain. ^[9] TG Therapeutics, New York, New York. ^[10] Instituciò Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain. ^[11] Department of Hematology, Vall d'Hebron University Hospital, Barcelona, Spain. ^[12] Experimental Hematology, Vall d'Hebron Institute of Oncology, Barcelona, Spain. ^[13] TG Therapeutics, New York, New York. groue@carrerasresearch.org enormant@tgtxinc.com. ^[14] Lymphoma Translational Group, Josep Carreras Leukaemia Research Institute, Badalona, Spain. groue@carrerasresearch.org enormant@tgtxinc.com. ^[15]