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首页> Cell death & disease> A novel function of NLRP3 independent of inflammasome as a key transcription factor of IL-33 in epithelial cells of atopic dermatitis.

A novel function of NLRP3 independent of inflammasome as a key transcription factor of IL-33 in epithelial cells of atopic dermatitis.

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作者： Jie,Zheng ^[1] ; Lu,Yao ^[2] ; Yijing,Zhou ^[1] ; Xiaoqun,Gu ^[3] ; Can,Wang ^[1] ; Kaifan,Bao ^[1] ; Yang,Sun ^[1] ; Min,Hong ^[1]

作者单位： Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, 210023, China. ^[1] Department of Pharmacology, School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, 210023, China. ^[2] Department of Biotherapy, Nanjing Jinling Hospital, Nanjing, 210002, China. ^[3] Department of Immunology, School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, 210023, China. ^[4] State Key Laboratory of Pharmaceutical Biotechnology, Chemistry and Biomedicine Innovation Center, School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing, 210023, China. ^[5] Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, 210023, China. minhong@njucm.edu.cn. ^[6]

主题词动物(Animals);骨化三醇(Calcitriol);细胞核(Cell Nucleus);皮炎, 特应性(Dermatitis, Atopic);疾病模型, 动物(Disease Models, Animal);上皮细胞(Epithelial Cells);基因表达调控(Gene Expression Regulation);人类(Humans);炎性体(Inflammasomes);干扰素调节因子类(Interferon Regulatory Factors);男(雄)性(Male);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 近交C57BL(Mice, Inbred C57BL);蛋白质结合(Protein Binding);RNA, 信使(RNA, Messenger);转录因子(Transcription Factors);小鼠(Mice)

DOI 10.1038/s41419-021-04159-9

PMID 34561424

发布时间 2024-03-24

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