Metabolomics analysis of the 3D L-02 cell cultures revealing the key role of metabolism of amino acids in ameliorating hepatotoxicity of perfluorooctanoic acid.

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第一作者： Ruijia,Zhang

第一单位： Sate Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China.

作者： Ruijia,Zhang ^[1] ; Wenhua,Lu ^[2] ; Yao,Yao ^[1] ; Lanyin,Tu ^[1] ; Tiantian,Yu ^[3] ; Tiangang,Luan ^[4] ; Baowei,Chen ^[5]

作者单位： Sate Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China. ^[1] Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou 510060, China. ^[2] Metabolic Innovation Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 540080, China. ^[3] Institute of Environmental and Ecological Engineering, Guangdong University of Technology, Guangzhou 510006, China. Electronic address: cesltg@mail.sysu.edu.cn. ^[4] Southern Marine Science and Engineering Guangdong Laboratory, School of Marine Sciences, Sun Yat-Sen University, Zhuhai 519082, China. Electronic address: chenbw5@mail.sysu.edu.cn. ^[5]

关键词 3D cell spheroids Amino acids Metabolomics Perfluorooctanoic acid

主题词氨基酸类(Amino Acids);辛酸盐类(Caprylates);细胞培养技术(Cell Culture Techniques);氟碳化合物(Fluorocarbons);人类(Humans);代谢组学(Metabolomics)

DOI 10.1016/j.scitotenv.2021.150438

PMID 34562763

发布时间 2021-11-30

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