Prodromal dysfunction of α5GABA-A receptor modulated hippocampal ripples occurs prior to neurodegeneration in the TgF344-AD rat model of Alzheimer's disease.

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第一作者： Marcia H,Ratner

第一单位： Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts, USA.

作者： Marcia H,Ratner ^[1] ; Scott S,Downing ^[1] ; Ouyang,Guo ^[2] ; KathrynAnn E,Odamah ^[1] ; Tara M,Stewart ^[1] ; Vidhya,Kumaresan ^[1] ; R Jonathan,Robitsek ^[1] ; Weiming,Xia ^[3] ; David H,Farb ^[4]

作者单位： Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts, USA. ^[1] Department of Biology, Boston University, Boston, Massachusetts, USA. ^[2] Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts, USA.;Geriatric Research Education and Clinical Center, Bedford Veterans Administration Healthcare System, Bedford, Massachusetts, USA. ^[3] Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts, USA.;Center for Systems Neuroscience, Boston University, Boston, Massachusetts, USA. ^[4]

关键词 Alzheimer's Consolidation Extra-synaptic Hippocampus Inhibition Memory Place cells Ripples TgF344-AD α5GABAA-R

DOI 10.1016/j.heliyon.2021.e07895

PMID 34568591

发布时间 2025-03-08

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2021年7卷9期

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Prodromal dysfunction of α5GABA-A receptor modulated hippocampal ripples occurs prior to neurodegeneration in the TgF344-AD rat model of Alzheimer's disease.

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Prodromal dysfunction of α5GABA-A receptor modulated hippocampal ripples occurs prior to neurodegeneration in the TgF344-AD rat model of Alzheimer's disease.

Heliyon

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