换一批Autophagy-mediated reduction of miR-345 contributes to hepatic cystogenesis in polycystic liver disease.
第一作者：
Tatyana,Masyuk
第一单位：
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
作者：
关键词
ADPKD, autosomal dominant polycystic kidney diseaseADPLD, autosomal dominant polycystic liver diseaseAGO2, Argonaute 2ALG8, alpha-1,3-glucosyltransferaseALG9, alpha-1,2-mannosyltransferaseARPKD, autosomal recessive polycystic kidney diseaseCDC25A, cell division cycle 25ACDK6, cyclin-dependent kinase 6Cell cycle-related proteinsCholangiocyte proliferationCholangiocytesDNAJB11, DnaJ heat shock protein family (Hsp40) member B11DZIP1L, DAZ interacting zinc finger protein 1 likeFDR, false discovery rateGANAB, glucosidase II alpha subunitGO, Gene OntologyGenetic liver diseasesHCQ, hydroxychloroquineISH, in situ hybridisationKEGG, Kyoto Encyclopedia of Genes and GenomesLRP5, low-density lipoprotein receptor-related protein 5NHC, normal human cholangiocyteNRC, normal rat cholangiocytePCK, polycystic kidneyPCKC, polycystic kidney rat cholangiocytePCNA, proliferating cell nuclear antigenPKD1/2, polycystic kidney disease 1/2PKHD1, polycystic kidney and hepatic disease 1PLD treatmentPLD, polycystic liver diseasePLDC, polycystic liver disease cholangiocytePRKCSH, protein kinase C substrate 80K-HRPM, reads per millionSEC61B, SEC61 translocon subunit betaSEC63, SEC63 homolog, protein translocation regulatorWT, wild typemTOR, mammalian target of rapamycinmiRISC, RNA-induced silencing complexmiRNA-seq, miRNA-sequencingsnRNA, small nuclear RNA
DOI
10.1016/j.jhepr.2021.100345
PMID
34568801
发布时间
2022-08-26
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JHEP reports
2021年3卷5期
100345页
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