换一批Increasing the heterologous production of spinosad in <i>Streptomyces albus</i> J1074 by regulating biosynthesis of its polyketide skeleton.
第一作者：
Ziheng,An
第一单位：
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education and Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, PR China.
作者：
关键词
2-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl)amino]ethanesulfonic acid, (TES)HPLC-high resolution mass spectrometer, (HPLC-HRMS)Heterologous productionLuria?Bertani, (LB)PolyketidePolyketide synthaseSpinosadSpinosynStreptomycesacetyl-CoA carboxylase, (ACC)acetyl-CoA synthetase, (AcsA)biosynthetic gene cluster, (BGC)high-performance liquid chromatography, (HPLC)limit of detection, (LoD)overlap extension-polymerase chain reaction, (OE-PCR)polyketide synthase, (PKS)propionyl-CoA carboxylase, (PCC)soya flour mannitol, (SFM)β and ε subunits of Acc, (AccBE)β and ε subunits of PCC, (PccBE)
DOI
10.1016/j.synbio.2021.09.008
PMID
34584996
发布时间
2024-04-03
- 浏览2
Synthetic and systems biotechnology
2021年6卷4期
292-301页
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