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Characterization of the molecular mechanisms underlying azithromycin-induced cardiotoxicity using human-induced pluripotent stem cell-derived cardiomyocytes.

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第一作者： Xiaochen,Wang

第一单位： Key Laboratory of combined Multi-organ Transplantation, Ministry of Public Health, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, China.;Institute of Translational Medicine, Zhejiang University, Hangzhou, 310029, China.

作者： Xiaochen,Wang ^[1] ; Ziwei,Pan ^[1] ; Jue,Wang ^[1] ; Hongkun,Wang ^[1] ; Hangping,Fan ^[1] ; Tingyu,Gong ^[1] ; Qiming,Sun ^[2] ; Ye,Feng ^[3] ; Ping,Liang ^[1]

作者单位： Key Laboratory of combined Multi-organ Transplantation, Ministry of Public Health, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, China.;Institute of Translational Medicine, Zhejiang University, Hangzhou, 310029, China. ^[1] Department of Biochemistry, Department of Cardiology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China. ^[2] Institute of Translational Medicine, Zhejiang University, Hangzhou, 310029, China.;Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China. ^[3]

关键词 QT interval autophagy azithromycin cardiotoxicity iPSC-CMs lysosome

医学主题词叠氮红霉素(Azithromycin);心脏毒素类(Cardiotoxins);细胞存活(Cell Survival);细胞, 培养的(Cells, Cultured);人类(Humans);诱导多能干细胞(Induced Pluripotent Stem Cells);肌细胞, 心脏(Myocytes, Cardiac)

DOI 10.1002/ctm2.549

PMID 34586730

发布时间 2022-02-07

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