Retrospective assessment of clonality of a legacy cell line by analytical subcloning of the master cell bank.

导出 LinkOut

翻译打印收藏纠错

作者： Guanghua Benson,Li ^[1] ; Jennifer,Pollard ^[1] ; Ren,Liu ^[1] ; Richard C,Stevens ^[2] ; Jorge,Quiroz ^[3] ; Michael C,Nelson ^[1] ; Matthew,Manahan ^[1] ; Nicholas,Murgolo ^[2] ; Robin S,Ehrick ^[1] ; Eric J,Wallenstein ^[4] ; Jason,Hughes ^[5] ; Yung-Shyeng,Tsao ^[1] ; Jia,Zhao ^[1] ; Zhimei,Du ^[1] ; Nihal,Tugcu ^[1] ; David,Pollard ^[1]

作者单位： Biologics Process Research & Development, Merck & Co., Inc., Kenilworth, New Jersey, USA. ^[1] Genetics and Pharmacogenomics, Merck & Co., Inc., Kenilworth, New Jersey, USA. ^[2] Research CMC Statistics, Merck & Co., Inc., Kenilworth, New Jersey, USA. ^[3] Biologics Process Development & Commercialization, Merck & Co., Inc., Kenilworth, New Jersey, USA. ^[4] Global Research IT, Merck & Co., Inc., Kenilworth, New Jersey, USA. ^[5]

关键词 acceptance sampling clonal origin clonality integration junction legacy cell lines monoclonal antibody subclones

主题词动物(Animals);CHO细胞(CHO Cells);仓鼠亚科(Cricetinae);仓鼠属(Cricetulus);遗传异质性(Genetic Heterogeneity);回顾性研究(Retrospective Studies)

DOI 10.1002/btpr.3215

PMID 34586757

发布时间 2022-05-05

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交