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G-CSF secreted by mutant IDH1 glioma stem cells abolishes myeloid cell immunosuppression and enhances the efficacy of immunotherapy.

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第一作者： Mahmoud S,Alghamri

第一单位： Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.;Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

作者： Mahmoud S,Alghamri ^[1] ; Brandon L,McClellan ^[2] ; Ruthvik P,Avvari ^[1] ; Rohit,Thalla ^[1] ; Stephen,Carney ^[1] ; Carson S,Hartlage ^[1] ; Santiago,Haase ^[1] ; Maria,Ventosa ^[1] ; Ayman,Taher ^[1] ; Neha,Kamran ^[1] ; Li,Zhang ^[1] ; Syed Mohd,Faisal ^[1] ; Felipe J,Núñez ^[1] ; María Belén,Garcia-Fabiani ^[1] ; Wajd N,Al-Holou ^[3] ; Daniel,Orringer ^[3] ; Shawn,Hervey-Jumper ^[4] ; Jason,Heth ^[3] ; Parag G,Patil ^[3] ; Karen,Eddy ^[3] ; Sofia D,Merajver ^[5] ; Peter J,Ulintz ^[5] ; Joshua,Welch ^[6] ; Chao,Gao ^[6] ; Jialin,Liu ^[6] ; Gabriel,Núñez ^[7] ; Dolores,Hambardzumyan ^[8] ; Pedro R,Lowenstein ^[9] ; Maria G,Castro ^[9]

作者单位： Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.;Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. ^[1] Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.;Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.;Graduate Program in Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. ^[2] Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA. ^[3] Department of Neurosurgery, University of California San Francisco, San Francisco, CA 94143, USA. ^[4] Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA. ^[5] Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI 48109, USA. ^[6] Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. ^[7] Department of Oncological Sciences, The Tisch Cancer Institute, and Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. ^[8] Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.;Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.;Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA. ^[9]

DOI 10.1126/sciadv.abh3243

PMID 34586841

发布时间 2024-09-23

基金项目

R21 NS107894/NS/NINDS NIH HHS/United States R01 NS122165/NS/NINDS NIH HHS/United States R01 NS105556/NS/NINDS NIH HHS/United States R01 NS082311/NS/NINDS NIH HHS/United States T32 CA009676/CA/NCI NIH HHS/United States R01 NS076991/NS/NINDS NIH HHS/United States R37 NS094804/NS/NINDS NIH HHS/United States R01 NS096756/NS/NINDS NIH HHS/United States

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G-CSF secreted by mutant IDH1 glioma stem cells abolishes myeloid cell immunosuppression and enhances the efficacy of immunotherapy.

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G-CSF secreted by mutant IDH1 glioma stem cells abolishes myeloid cell immunosuppression and enhances the efficacy of immunotherapy.

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