Epigenetic induction of lipocalin 2 expression drives acquired resistance to 5-fluorouracil in colorectal cancer through integrin β3/SRC pathway.-论文-万方医学网

作者： Wenyi,Zhang ^[1] ; Rulu,Pan ^[2] ; Mei,Lu ^[1] ; Qian,Zhang ^[1] ; Ziqi,Lin ^[1] ; Yuan,Qin ^[1] ; Zhanyu,Wang ^[1] ; Siqing,Gong ^[1] ; Huan,Lin ^[1] ; Shuyi,Chong ^[1] ; Liting,Lu ^[1] ; Wanqin,Liao ^[1] ; Xincheng,Lu ^[3]

作者单位： School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325035, China. ^[1] Department of Radiotherapy, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. ^[2] Department of Basic Medicine and Biomedical Engineering, Foshan University, Foshan, 528200, China. ^[3] School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325035, China. xinchenglu@yahoo.com. ^[4]

主题词动物(Animals);细胞系, 肿瘤(Cell Line, Tumor);结直肠肿瘤(Colorectal Neoplasms);DNA甲基化(DNA Methylation);抗药性, 肿瘤(Drug Resistance, Neoplasm);后成说, 遗传(Epigenesis, Genetic);氟尿嘧啶(Fluorouracil);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);HT29细胞(HT29 Cells);人类(Humans);整合素β3(Integrin beta3);男(雄)性(Male);小鼠(Mice);NF-κB(NF-kappa B);肿瘤移植(Neoplasm Transplantation);预后(Prognosis);启动区, 遗传(Promoter Regions, Genetic);蛋白质稳定性(Protein Stability);信号传导(Signal Transduction);增量调节(Up-Regulation);src族激酶类(src-Family Kinases)

DOI 10.1038/s41388-021-02029-4

PMID 34588619

发布时间 2022-10-26

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Epigenetic induction of lipocalin 2 expression drives acquired resistance to 5-fluorouracil in colorectal cancer through integrin β3/SRC pathway.

Oncogene

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Oncogene

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Epigenetic induction of lipocalin 2 expression drives acquired resistance to 5-fluorouracil in colorectal cancer through integrin β3/SRC pathway.

Oncogene

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Oncogene

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