换一批
换一批Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation.
第一作者：
Qi,Lv
第一单位：
Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Stake Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
作者：
关键词
3-MC, 3-methylcholanthrene5-ASA, 5-aminosalicylic acidAIM2, absent in melanoma 2ATG5, autophagy-related protein 5ATG7, autophagy-related protein 7ATP, adenosine triphosphateAutophagyBMDMs, bone marrow-derived macrophagesCETSA, cellular thermal shift assayCHX, cycloheximideChIP, chromatin immunoprecipitationColitisDAI, disease activity indexDAMPs, damage-associated molecular patternsDMSO, dimethyl sulfoxideDSS, dextran sulfate sodiumDTT, dithiothreitolECL, enhanced chemiluminescentEDTA, ethylenediaminetetraacetic acidELISA, enzyme-linked immunosorbent assayEZH2EZH2, enhancer of zeste homolog 2FBS, fetal bovine serumH&E, hematoxylin and eosinLPS, lipopolysaccharideLonicerinM-CSF, macrophage colony stimulating factorMDP, muramyldipeptideMPO, myeloperoxidaseMSU, monosodium urate crystalsNLRP3 inflammasomeNLRP3, nucleotide-binding domain-like receptors family pyrin domain containing 3PAMPs, pathogen-associated molecular patternsPMA, phorbol myristate acetatePMSF, phenylmethanesulfonyl fluoridePRC2, polycomb repressive complex 2RMSD, root mean-square deviationRMSF, root mean-square fluctuationSIP, solvent-induced protein precipitationTEM, transmission electron microscopyUC, ulcerative colitis
DOI
10.1016/j.apsb.2021.03.011
PMID
34589402
发布时间
2021-10-01
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Acta pharmaceutica Sinica. B
2021年11卷9期
2880-2899页
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