The impact of anatomical changes during photon or proton based radiation treatment on tumor dose in glioblastoma dose escalation trials.

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作者： Eline D,Hessen ^[1] ; Sebastian,Makocki ^[2] ; Uulke A,van der Heide ^[1] ; Bas,Jasperse ^[3] ; Lotte J,Lutkenhaus ^[1] ; Emmy,Lamers ^[1] ; Eugène,Damen ^[1] ; Esther G C,Troost ^[4] ; Gerben R,Borst ^[5]

作者单位： Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, Netherlands. ^[1] Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, and Helmholtz-Zentrum Dresden-Rossendorf, Germany. ^[2] Department of Radiology, The Netherlands Cancer Institute, Amsterdam, Netherlands. ^[3] Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, and Helmholtz-Zentrum Dresden-Rossendorf, Germany; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiooncology - OncoRay, Germany; German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany; National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany; Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Germany. ^[4] Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, Netherlands; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom; The Christie NHS Foundation Trust, Department of Radiotherapy Related Research, The Christie National Health Trust, Manchester, United Kingdom. Electronic address: gerben.borst@nhs.net. ^[5]

关键词 Anatomical changes Dose escalation trials Glioblastoma Radiotherapy Repeated MRI Target volume changes

主题词胶质母细胞瘤(Glioblastoma);人类(Humans);光子(Photons);质子(Protons);放射治疗剂量(Radiotherapy Dosage);放射治疗计划, 计算机辅助(Radiotherapy Planning, Computer-Assisted);放射疗法, 调强适形(Radiotherapy, Intensity-Modulated)

DOI 10.1016/j.radonc.2021.09.022

PMID 34592361

发布时间 2024-02-10

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