Antibiotic Usage Reduced Overall Survival by over 70% in Non-small Cell Lung Cancer Patients on Anti-PD-1 Immunotherapy.

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第一作者： Kazuyuki,Hamada

第一单位： Division of Medical Oncology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.;Department of Surgery, University of California, San Diego, CA, U.S.A.;AntiCancer Inc., San Diego, CA, U.S.A.

作者： Kazuyuki,Hamada ^[1] ; Kiyoshi,Yoshimura ^[2] ; Yuya,Hirasawa ^[3] ; Masahiro,Hosonuma ^[4] ; Masakazu,Murayama ^[5] ; Yoichiro,Narikawa ^[5] ; Hirotsugu,Ariizumi ^[3] ; Ryotaro,Ohkuma ^[3] ; Midori,Shida ^[5] ; Yutaro,Kubota ^[3] ; Satoshi,Matsukuma ^[3] ; Tomoyuki,Ishiguro ^[3] ; Takehiko,Sambe ^[6] ; Atsushi,Horiike ^[3] ; Atsuo,Kuramasu ^[5] ; Satoshi,Wada ^[7] ; Junji,Tsurutani ^[8] ; Eisuke,Inoue ^[9] ; Naoki,Uchida ^[6] ; Yuji,Kiuchi ^[10] ; Shinichi,Kobayashi ^[11] ; Robert M,Hoffman ^[12] ; Takuya,Tsunoda ^[3]

作者单位： Division of Medical Oncology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.;Department of Surgery, University of California, San Diego, CA, U.S.A.;AntiCancer Inc., San Diego, CA, U.S.A. ^[1] Division of Medical Oncology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan; kyoshim1@med.showa-u.ac.jp.;Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, Tokyo, Japan. ^[2] Division of Medical Oncology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan. ^[3] Division of Medical Oncology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.;Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, Tokyo, Japan. ^[4] Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, Tokyo, Japan. ^[5] Division of Clinical Pharmacology, Department of Pharmacology, Showa University School of Medicine, Tokyo, Japan.;Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, Tokyo, Japan. ^[6] Division of Medical Oncology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.;Department of Clinical Diagnostic Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, Tokyo, Japan. ^[7] Advanced Cancer Translational Research Institute, Showa University, Tokyo, Japan. ^[8] Research Administration Center, Showa University, Tokyo, Japan. ^[9] Department of Pharmacology, Showa University School of Medicine, Tokyo, Japan. ^[10] Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, Tokyo, Japan. ^[11] Department of Surgery, University of California, San Diego, CA, U.S.A.;AntiCancer Inc., San Diego, CA, U.S.A. ^[12]

关键词 Antibiotics gut microbiota immune checkpoint inhibitors non-small cell lung cancer survival