Monitoring the weight and dimensional expansion of pyridostigmine bromide tablets under dynamic vapor sorption and impact of deliquescence on tablet strength and drug release.

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第一作者： Ioannis,Partheniadis

第一单位： Department of Pharmaceutical Technology, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece.

作者： Ioannis,Partheniadis ^[1] ; Despoina,Kopanelou ^[1] ; Michael,Gamlen ^[2] ; Ioannis,Nikolakakis ^[3]

作者单位： Department of Pharmaceutical Technology, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece. ^[1] Pharmaceutical Development Services Ltd, BioCity Nottingham, Nottingham NG1 1GF, UK. ^[2] Department of Pharmaceutical Technology, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece. Electronic address: yannikos@pharm.auth.gr. ^[3]

关键词 Deliquescence Isotherms Moisture Raman Tablet dimensions Tablet weight Tableting

主题词湿度(Humidity);溴吡斯的明(Pyridostigmine Bromide);片剂(Tablets);X线衍射(X-Ray Diffraction)

DOI 10.1016/j.ijpharm.2021.121150

PMID 34600060

发布时间 2021-11-09

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