Cell-free DNA and circulating tumor cell kinetics in a pre-clinical head and neck Cancer model undergoing radiation therapy.

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作者： Nidal,Muhanna ^[1] ; Donovan,Eu ^[2] ; Harley H L,Chan ^[2] ; Catriona,Douglas ^[2] ; Jason L,Townson ^[2] ; Marco A,Di Grappa ^[3] ; Reza M,Mohamadi ^[4] ; Shana O,Kelley ^[4] ; Scott V,Bratman ^[5] ; Jonathan C,Irish ^[6]

作者单位： Princess Margaret Cancer Center, University Health Network, Toronto, ON, Canada. nidal.muhanna@uhn.ca.;TECHNA Institute, Guided Therapeutic (GTx) Program, University Health Network, Toronto, ON, Canada. nidal.muhanna@uhn.ca.;Department of Otolaryngology-Head and Neck Surgery-Surgical Oncology, University of Toronto, Toronto, Ontario, Canada. nidal.muhanna@uhn.ca.;Department of Otolaryngology-Head and Neck Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel. nidal.muhanna@uhn.ca. ^[1] Princess Margaret Cancer Center, University Health Network, Toronto, ON, Canada.;TECHNA Institute, Guided Therapeutic (GTx) Program, University Health Network, Toronto, ON, Canada. ^[2] Princess Margaret Cancer Center, University Health Network, Toronto, ON, Canada. ^[3] Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada. ^[4] Princess Margaret Cancer Center, University Health Network, Toronto, ON, Canada.;Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada. ^[5] Princess Margaret Cancer Center, University Health Network, Toronto, ON, Canada.;TECHNA Institute, Guided Therapeutic (GTx) Program, University Health Network, Toronto, ON, Canada.;Department of Otolaryngology-Head and Neck Surgery-Surgical Oncology, University of Toronto, Toronto, Ontario, Canada. ^[6]

关键词 Circulating tumor DNA Circulating tumor cell Head and neck cancer Oral cavity cancer preclinical model Rabbit Radiation VX2