Effective killing of cells expressing CD276 (B7-H3) by a bispecific T cell engager based on a new fully human antibody.

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第一作者： Xianglei,Liu

第一单位： Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, S843 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, United States; State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing, East China University of Science and Technology, Shanghai 200237, China. Electronic address: xianglei922@sina.com.

作者： Xianglei,Liu ^[1] ; Doncho,Zhelev ^[2] ; Cynthia,Adams ^[2] ; Chuan,Chen ^[2] ; John W,Mellors ^[3] ; Dimiter S,Dimitrov ^[4]

作者单位： Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, S843 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, United States; State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing, East China University of Science and Technology, Shanghai 200237, China. Electronic address: xianglei922@sina.com. ^[1] Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, S843 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, United States. ^[2] Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, S843 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, United States; State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing, East China University of Science and Technology, Shanghai 200237, China. ^[3] Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, S843 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, United States; Abound Bio, 1401 Forbes Ave, Pittsburgh, PA 15219, United States. Electronic address: mit666666@pitt.edu. ^[4]

关键词 Bispecific T cell engager (BiTE)CD276 (B7-H3)Fully human antibody V1/V2 domain

DOI 10.1016/j.tranon.2021.101232

PMID 34601396

发布时间 2021-10-25

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