Intradermal-delivered DNA vaccine induces durable immunity mediating a reduction in viral load in a rhesus macaque SARS-CoV-2 challenge model.

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第一作者： Ami,Patel

第一单位： Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA.

作者： Ami,Patel ^[1] ; Jewell N,Walters ^[2] ; Emma L,Reuschel ^[1] ; Katherine,Schultheis ^[2] ; Elizabeth,Parzych ^[1] ; Ebony N,Gary ^[1] ; Igor,Maricic ^[2] ; Mansi,Purwar ^[1] ; Zeena,Eblimit ^[2] ; Susanne N,Walker ^[1] ; Diana,Guimet ^[2] ; Pratik,Bhojnagarwala ^[1] ; Opeyemi S,Adeniji ^[1] ; Arthur,Doan ^[2] ; Ziyang,Xu ^[1] ; Dustin,Elwood ^[2] ; Sophia M,Reeder ^[1] ; Laurent,Pessaint ^[3] ; Kevin Y,Kim ^[1] ; Anthony,Cook ^[3] ; Neethu,Chokkalingam ^[1] ; Brad,Finneyfrock ^[3] ; Edgar,Tello-Ruiz ^[1] ; Alan,Dodson ^[3] ; Jihae,Choi ^[1] ; Alison,Generotti ^[2] ; John,Harrison ^[3] ; Nicholas J,Tursi ^[1] ; Viviane M,Andrade ^[2] ; Yaya,Dia ^[1] ; Faraz I,Zaidi ^[1] ; Hanne,Andersen ^[3] ; Mohamed,Abdel-Mohsen ^[1] ; Mark G,Lewis ^[3] ; Kar,Muthumani ^[1] ; J Joseph,Kim ^[2] ; Daniel W,Kulp ^[1] ; Laurent M,Humeau ^[2] ; Stephanie J,Ramos ^[2] ; Trevor R F,Smith ^[2] ; David B,Weiner ^[1] ; Kate E,Broderick ^[2]

作者单位： Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA. ^[1] Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA. ^[2] Bioqual, Rockville, MD 20852, USA. ^[3]

关键词 COVID-19 ID DNA vaccine SARS-CoV-2 challenge coronavirus electroporation infectious disease macaque protection

主题词动物(Animals);抗体, 中和(Antibodies, Neutralizing);抗体, 病毒(Antibodies, Viral);女(雌)性(Female);注射, 皮内(Injections, Intradermal);肺(Lung);猕猴(Macaca mulatta);男(雄)性(Male);T淋巴细胞(T-Lymphocytes);疫苗, DNA(Vaccines, DNA);病毒载量(Viral Load)

DOI 10.1016/j.xcrm.2021.100420

PMID 34604818

发布时间 2022-06-30

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Cell reports. Medicine

2021年2卷10期

100420页

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Intradermal-delivered DNA vaccine induces durable immunity mediating a reduction in viral load in a rhesus macaque SARS-CoV-2 challenge model.

Cell reports. Medicine

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Intradermal-delivered DNA vaccine induces durable immunity mediating a reduction in viral load in a rhesus macaque SARS-CoV-2 challenge model.

Cell reports. Medicine

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Cell reports. Medicine

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