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首页> Experimental and molecular pathology> Pimitespib is effective on cecal GIST in a mouse model of familial GISTs with KIT-Asp820Tyr mutation through KIT signaling inhibition.

Pimitespib is effective on cecal GIST in a mouse model of familial GISTs with KIT-Asp820Tyr mutation through KIT signaling inhibition.

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作者： Takako,Kihara ^[1] ; Jiayin,Yuan ^[1] ; Tadashi,Watabe ^[2] ; Kazuhiro,Kitajima ^[3] ; Neinei,Kimura ^[1] ; Mizuka,Ohkouchi ^[1] ; Yuka,Hashikura ^[1] ; Shuichi,Ohkubo ^[4] ; Tsuyoshi,Takahashi ^[5] ; Seiichi,Hirota ^[6]

作者单位： Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan. ^[1] Department of Radiology, Osaka University Graduate School of Medicine, Suita, Japan. ^[2] Department of Radiology, Hyogo College of Medicine, Nishinomiya, Japan. ^[3] Discovery and Preclinical Research Division, Taiho Pharmaceutical Co. Ltd, Tsukuba, Japan. ^[4] Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Japan. ^[5] Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan. Electronic address: hiros@hyo-med.ac.jp. ^[6]

关键词 Exon 17 Gastrointestinal stromal tumor Heat shock protein 90 inhibitor Knock-in mouse TAS-116 (Pimitespib)c-kit gene

主题词动物(Animals);抗肿瘤药(Antineoplastic Agents);苯甲酰胺类(Benzamides);细胞增殖(Cell Proliferation);疾病模型, 动物(Disease Models, Animal);胃肠道间质肿瘤(Gastrointestinal Stromal Tumors);人类(Humans);小鼠(Mice);突变(Mutation);磷酰化(Phosphorylation);原癌基因蛋白质类c-kit(Proto-Oncogene Proteins c-kit);吡唑类(Pyrazoles);信号传导(Signal Transduction)

DOI 10.1016/j.yexmp.2021.104692

PMID 34606780

发布时间 2021-12-23

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Experimental and molecular pathology

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