lncRNA THAP7-AS1, transcriptionally activated by SP1 and post-transcriptionally stabilized by METTL3-mediated m6A modification, exerts oncogenic properties by improving CUL4B entry into the nucleus.
第一作者:
Hai-Ting,Liu
第一单位:
Key Laboratory for Experimental Teratology of the Ministry of Education and Department of Pathology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, P.R. China.;Department of Pathology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, P.R. China.
作者:
医学主题词
细胞系, 肿瘤(Cell Line, Tumor);细胞运动(Cell Movement);细胞增殖(Cell Proliferation);CULLIN蛋白质类(Cullin Proteins);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);甲基转移酶类(Methyltransferases);微RNAs(MicroRNAs);核定位信号(Nuclear Localization Signals);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);Sp1转录因子(Sp1 Transcription Factor);胃肿瘤(Stomach Neoplasms)
DOI
10.1038/s41418-021-00879-9
PMID
34608273
发布时间
2025-11-12
- 浏览4
Cell death and differentiation
627-641页
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