The TGF-β/HDAC7 axis suppresses TCA cycle metabolism in renal cancer.

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作者： Hyeyoung,Nam ^[1] ; Anirban,Kundu ^[1] ; Suman,Karki ^[1] ; Garrett J,Brinkley ^[1] ; Darshan S,Chandrashekar ^[2] ; Richard L,Kirkman ^[1] ; Juan,Liu ^[3] ; Maria V,Liberti ^[3] ; Jason W,Locasale ^[3] ; Tanecia,Mitchell ^[1] ; Sooryanarayana,Varambally ^[2] ; Sunil,Sudarshan ^[4]

作者单位： Department of Urology and. ^[1] Department of Pathology, University of Alabama at Birmingham (UAB), Birmingham, Alabama, USA. ^[2] Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina, USA. ^[3] O'Neal Comprehensive Cancer Center, UAB, Birmingham, Alabama, USA. ^[4] Birmingham Veterans Affairs Medical Center, Birmingham, Alabama, USA. ^[5]

关键词 Cancer Cell Biology Mitochondria Molecular biology

主题词动物(Animals);柠檬酸循环(Citric Acid Cycle);基因表达谱(Gene Expression Profiling);组蛋白脱乙酰基酶类(Histone Deacetylases);人类(Humans);肾肿瘤(Kidney Neoplasms);小鼠(Mice);转染(Transfection);转化生长因子β(Transforming Growth Factor beta)

DOI 10.1172/jci.insight.148438

PMID 34609963

发布时间 2022-03-07

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2021年6卷22期

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The TGF-β/HDAC7 axis suppresses TCA cycle metabolism in renal cancer.

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The TGF-β/HDAC7 axis suppresses TCA cycle metabolism in renal cancer.

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