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Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels.

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第一作者： Isabel,Kurth

第一单位： Inspirna, Inc., 310 E. 67th St, New York, NY 10065, USA.

作者： Isabel,Kurth ^[1] ; Norihiro,Yamaguchi ^[2] ; Celia,Andreu-Agullo ^[1] ; Helen S,Tian ^[2] ; Subhasree,Sridhar ^[1] ; Shugaku,Takeda ^[1] ; Foster C,Gonsalves ^[1] ; Jia Min,Loo ^[3] ; Afsar,Barlas ^[4] ; Katia,Manova-Todorova ^[4] ; Robert,Busby ^[1] ; Johanna C,Bendell ^[5] ; James,Strauss ^[6] ; Marwan,Fakih ^[7] ; Autumn J,McRee ^[8] ; Andrew E,Hendifar ^[9] ; Lee S,Rosen ^[10] ; Andrea,Cercek ^[4] ; Robert,Wasserman ^[1] ; Michael,Szarek ^[11] ; Scott L,Spector ^[1] ; Syed,Raza ^[1] ; Masoud F,Tavazoie ^[1] ; Sohail F,Tavazoie ^[2]

作者单位： Inspirna, Inc., 310 E. 67th St, New York, NY 10065, USA. ^[1] Laboratory of Systems Cancer Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. ^[2] Laboratory of Systems Cancer Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.;Laboratory of Precision Oncology and Tumor Evolution, Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore. ^[3] Memorial Sloan Kettering Cancer Center, 275 York Ave., New York, NY 10065, USA. ^[4] Sarah Cannon Research Institute, 250 25th Ave N, Nashville, TN 37203, USA. ^[5] Mary Crowley Cancer Research, Building C, 7777 Forest Ln #707, Dallas, TX 75230, USA. ^[6] City of Hope Comprehensive Cancer Center, 1500 E Duarte Rd, Duarte, CA 91010, USA. ^[7] The University of North Carolina at Chapel Hill, 27599 Chapel Hill, NC, USA. ^[8] Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA. ^[9] Jonsson Comprehensive Cancer Center, University of California, 10833 Le Conte Ave, Los Angeles, CA 90024, USA. ^[10] Inspirna, Inc., 310 E. 67th St, New York, NY 10065, USA.;University of Colorado School of Medicine, 13001 E 17th Pl, Aurora, CO 80045, USA.;SUNY Downstate Health Sciences University School of Public Health, 450 Clarkson Ave, Brooklyn, NY 11203, USA. ^[11]

医学主题词动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);结肠肿瘤(Colonic Neoplasms);结直肠肿瘤(Colorectal Neoplasms);肌酸(Creatine);人类(Humans);膜转运蛋白质类(Membrane Transport Proteins);小鼠(Mice);小鼠, 裸(Mice, Nude);突变(Mutation);神经组织蛋白质类(Nerve Tissue Proteins);质膜神经递质转运蛋白质类(Plasma Membrane Neurotransmitter Transport Proteins);原癌基因蛋白质类p21(ras)(Proto-Oncogene Proteins p21(ras))

DOI 10.1126/sciadv.abi7511

PMID 34613776

发布时间 2024-09-23

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Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels.

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Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels.

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