Dual kinetics of OATP2B1: Inhibitory potency and pH-dependence of OATP2B1 inhibitors.

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第一作者： Ryo,Sato

第一单位： Graduate School of Pharmaceutical Sciences, Keio University, 1-5-30, Shibakoen, Minato-ku, Tokyo, 105-8512, Japan. Electronic address: ryosato0429@gmail.com.

作者： Ryo,Sato ^[1] ; Takeshi,Akiyoshi ^[2] ; Tokio,Morita ^[3] ; Kazuhiro,Katayama ^[4] ; Kodai,Yajima ^[5] ; Hiroki,Kataoka ^[6] ; Ayuko,Imaoka ^[7] ; Hisakazu,Ohtani ^[8]

作者单位： Graduate School of Pharmaceutical Sciences, Keio University, 1-5-30, Shibakoen, Minato-ku, Tokyo, 105-8512, Japan. Electronic address: ryosato0429@gmail.com. ^[1] Graduate School of Pharmaceutical Sciences, Keio University, 1-5-30, Shibakoen, Minato-ku, Tokyo, 105-8512, Japan. Electronic address: akiyoshi-tk@pha.keio.ac.jp. ^[2] Graduate School of Pharmaceutical Sciences, Keio University, 1-5-30, Shibakoen, Minato-ku, Tokyo, 105-8512, Japan. Electronic address: morita.tokio@keio.jp. ^[3] School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba, 274-8555, Japan. Electronic address: katayama.kazuhiro@nihon-u.ac.jp. ^[4] Graduate School of Pharmaceutical Sciences, Keio University, 1-5-30, Shibakoen, Minato-ku, Tokyo, 105-8512, Japan. Electronic address: kodai.ss-kp8181@keio.jp. ^[5] Graduate School of Pharmaceutical Sciences, Keio University, 1-5-30, Shibakoen, Minato-ku, Tokyo, 105-8512, Japan. Electronic address: kataoka-hrk@keio.jp. ^[6] Graduate School of Pharmaceutical Sciences, Keio University, 1-5-30, Shibakoen, Minato-ku, Tokyo, 105-8512, Japan. Electronic address: imaoka-ay@pha.keio.ac.jp. ^[7] Graduate School of Pharmaceutical Sciences, Keio University, 1-5-30, Shibakoen, Minato-ku, Tokyo, 105-8512, Japan. Electronic address: ohtani-tky@umin.net. ^[8]

关键词 Bimodal kinetics Drug-drug interaction High- and low-affinity components NSAIDs OATP2B1 pH-dependent

主题词生物转运(Biological Transport);雌酮(Estrone);氢离子浓度(Hydrogen-Ion Concentration);动力学(Kinetics);有机阴离子转运子(Organic Anion Transporters);磺溴酞(Sulfobromophthalein)

DOI 10.1016/j.dmpk.2021.100416

PMID 34619547

发布时间 2022-01-13

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