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Safety, pharmacokinetics and antiviral activity of PGT121, a broadly neutralizing monoclonal antibody against HIV-1: a randomized, placebo-controlled, phase 1 clinical trial.

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第一作者: Kathryn E,Stephenson
第一单位: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.;Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA, USA.;Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
作者单位: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.;Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA, USA.;Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. [1] Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.;Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.;Infectious Disease Division, Massachusetts General Hospital, Boston, MA, USA. [2] Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.;Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA, USA. [3] Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA. [4] Orlando Immunology Center, Orlando, FL, USA. [5] McGovern Medical School at The University of Texas Health Science Center, Houston, TX, USA. [6] International AIDS Vaccine Initiative, New York, NY, USA. [7] Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. [8] Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM, USA. [9] Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. [10] Duke Human Vaccine Institute, Duke University, Durham, NC, USA.;Departments of Surgery, Immunology and Molecular Genetics and Microbiology, Duke University, Durham, NC, USA. [11] Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM, USA.;New Mexico Consortium, Los Alamos, NM, USA. [12] Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA. dbarouch@bidmc.harvard.edu.;Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA, USA. dbarouch@bidmc.harvard.edu.;Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. dbarouch@bidmc.harvard.edu. [13]
DOI 10.1038/s41591-021-01509-0
PMID 34621054
发布时间 2024-03-02
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