Pharmacological blockade of the EP3 prostaglandin E<sub>2</sub> receptor in the setting of type 2 diabetes enhances β-cell proliferation and identity and relieves oxidative damage.

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第一作者： Karin J,Bosma

第一单位： Dept. of Veterans Affairs Tennessee Valley Authority, Nashville, TN, USA; Dept. of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

作者： Karin J,Bosma ^[1] ; Spencer R,Andrei ^[1] ; Liora S,Katz ^[2] ; Ashley A,Smith ^[3] ; Jennifer C,Dunn ^[1] ; Valerie F,Ricciardi ^[4] ; Marisol A,Ramirez ^[5] ; Sharon,Baumel-Alterzon ^[2] ; William A,Pace ^[6] ; Darian T,Carroll ^[3] ; Emily M,Overway ^[3] ; Elysa M,Wolf ^[7] ; Michelle E,Kimple ^[8] ; Quanhu,Sheng ^[5] ; Donald K,Scott ^[2] ; Richard M,Breyer ^[1] ; Maureen,Gannon ^[9]

作者单位： Dept. of Veterans Affairs Tennessee Valley Authority, Nashville, TN, USA; Dept. of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. ^[1] Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ^[2] Dept. of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA. ^[3] Dept. of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. ^[4] Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA; Dept. of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA. ^[5] Dept. of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA. ^[6] Program in Cancer Biology, Vanderbilt University, Nashville, TN, USA. ^[7] Dept. of Medicine, University of Wisconsin, Madison, WI, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA. ^[8] Dept. of Veterans Affairs Tennessee Valley Authority, Nashville, TN, USA; Dept. of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Dept. of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA. Electronic address: Maureen.gannon@vumc.org. ^[9]

关键词 Beta cell proliferation Mouse model Nrf2 Prostaglandin E(2)Type 2 diabetes

主题词动物(Animals);细胞增殖(Cell Proliferation);糖尿病, 2型(Diabetes Mellitus, Type 2);胰岛素分泌细胞(Insulin-Secreting Cells);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 肥胖(Mice, Obese);氧化性应激(Oxidative Stress);受体, 前列腺素E, EP3亚型(Receptors, Prostaglandin E, EP3 Subtype)

DOI 10.1016/j.molmet.2021.101347

PMID 34626853

发布时间 2024-10-24

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Molecular metabolism

2021年54卷

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Pharmacological blockade of the EP3 prostaglandin E<sub>2</sub> receptor in the setting of type 2 diabetes enhances β-cell proliferation and identity and relieves oxidative damage.

Molecular metabolism

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Molecular metabolism

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Pharmacological blockade of the EP3 prostaglandin E<sub>2</sub> receptor in the setting of type 2 diabetes enhances β-cell proliferation and identity and relieves oxidative damage.

Molecular metabolism

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Molecular metabolism

相关期刊

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