首页> European journal of medicinal chemistry> 1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity.

1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity.

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第一作者： Alice,Legru

第一单位： IBMM, CNRS, Univ Montpellier, ENSCM, Montpellier, France.

作者： Alice,Legru ^[1] ; Federica,Verdirosa ^[2] ; Jean-François,Hernandez ^[3] ; Giusy,Tassone ^[4] ; Filomena,Sannio ^[2] ; Manuela,Benvenuti ^[4] ; Pierre-Alexis,Conde ^[1] ; Guillaume,Bossis ^[5] ; Caitlyn A,Thomas ^[6] ; Michael W,Crowder ^[6] ; Melissa,Dillenberger ^[7] ; Katja,Becker ^[7] ; Cecilia,Pozzi ^[4] ; Stefano,Mangani ^[4] ; Jean-Denis,Docquier ^[8] ; Laurent,Gavara ^[9]

作者单位： IBMM, CNRS, Univ Montpellier, ENSCM, Montpellier, France. ^[1] Dipartimento di Biotecnologie Mediche, Università di Siena, 53100, Siena, Italy. ^[2] IBMM, CNRS, Univ Montpellier, ENSCM, Montpellier, France. Electronic address: jean-francois.hernandez@umontpellier.fr. ^[3] Dipartimento di Biotecnologie, Chimica e Pharmacia, Università di Siena, 53100, Siena, Italy. ^[4] IGMM, Univ Montpellier, CNRS, Montpellier, France. ^[5] Department of Chemistry and Biochemistry, Miami University, Oxford, OH, USA. ^[6] Chair of Biochemistry and Molecular Biology, Interdisciplinary Research Center, Justus Liebig University, D-35392, Giessen, Germany. ^[7] Dipartimento di Biotecnologie Mediche, Università di Siena, 53100, Siena, Italy; Centre d'Ingénierie des Protéines-InBioS, Université de Liège, B-4000, Liège, Belgium. Electronic address: jddocquier@unisi.it. ^[8] IBMM, CNRS, Univ Montpellier, ENSCM, Montpellier, France. Electronic address: laurent.gavara@umontpellier.fr. ^[9]

关键词 1,2,4-Triazole-3-thione Bacterial resistance Metallo-β-Lactamase inhibitor Thioether β-lactam antibiotic