Erythropoietin Abrogates Post-Ischemic Activation of the NLRP3, NLRC4, and AIM2 Inflammasomes in Microglia/Macrophages in a TAK1-Dependent Manner.

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作者： Ole,Heinisch ^[1] ; Thomas,Zeyen ^[1] ; Tobias,Goldmann ^[2] ; Marco,Prinz ^[3] ; Michael,Huber ^[3] ; Jennifer,Jung ^[4] ; Eren,Arik ^[5] ; Shahin,Habib ^[6] ; Alexander,Slowik ^[1] ; Arno,Reich ^[1] ; Jörg B,Schulz ^[7] ; Pardes,Habib ^[8]

作者单位： Department of Neurology, Medical Faculty, RWTH Aachen University, Pauwelsstraße 30, D-52074, Aachen, Germany. ^[1] Department of Neurology, University Hospital of Bonn, Bonn, Germany. ^[2] Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany. ^[3] Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany. ^[4] Center for Basics in NeuroModulation (NeuroModulBasics), Faculty of Medicine, University of Freiburg, Freiburg, Germany. ^[5] Institute of Biochemistry and Molecular Immunology, Medical Faculty, RWTH Aachen University, Aachen, Germany. ^[6] Medical Biochemistry, Department of Biochemistry, University of Leicester, Leicester, UK. ^[7] Department of Anatomy and Cell Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany. ^[8] JARA-BRAIN Institute of Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich GmbH and RWTH Aachen University, Aachen, Germany. ^[9] Department of Neurology, Medical Faculty, RWTH Aachen University, Pauwelsstraße 30, D-52074, Aachen, Germany. phabib@ukaachen.de. ^[10] Institute of Biochemistry and Molecular Immunology, Medical Faculty, RWTH Aachen University, Aachen, Germany. phabib@ukaachen.de. ^[11] JARA-BRAIN Institute of Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich GmbH and RWTH Aachen University, Aachen, Germany. phabib@ukaachen.de. ^[12]

关键词 EPO Inflammasomes Microglia Neuroinflammation Stroke TAK1