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Integrative epigenomic and high-throughput functional enhancer profiling reveals determinants of enhancer heterogeneity in gastric cancer.

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作者单位: Department of Biochemistry, National University of Singapore, Singapore, 117596, Singapore. [1] Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, 169857, Singapore. [2] Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. [3] Epigenetic and Epitranscriptomic Regulation, Genome Institute of Singapore, Singapore, 138672, Singapore. [4] The Institute for Genomics and Systems Biology, The University of Chicago, Chicago, Illinois, USA. [5] Precision Medicine and Population Genomics (Somatic), Genome Institute of Singapore, Singapore, 138672, Singapore. [6] Cardiovascular Research Institute, National University Health System, Singapore, 119074, Singapore. [7] Precision Medicine and Population Genomics (Germline), Genome Institute of Singapore, Singapore, Singapore. [8] Montreal Heart Institute, Montreal, Canada. [9] Department of Medicine, University of Montreal, Montreal, Canada. [10] Department of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, USA. [11] Department of Haematology-Oncology, National University Cancer Institute Singapore, National University Hospital, Singapore, 119074, Singapore. [12] Biostatistics Unit, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore. [13] The Institute for Genomics and Systems Biology, The University of Chicago, Chicago, Illinois, USA. kevin@tempus.com. [14] Tempus Labs, Chicago, USA. kevin@tempus.com. [15] Department of Biochemistry, National University of Singapore, Singapore, 117596, Singapore. csisjha@nus.edu.sg. [16] Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. csisjha@nus.edu.sg. [17] NUS Center for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117599, Singapore. csisjha@nus.edu.sg. [18] Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, USA. csisjha@nus.edu.sg. [19] Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, 169857, Singapore. gmstanp@duke-nus.edu.sg. [20] Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. gmstanp@duke-nus.edu.sg. [21] Epigenetic and Epitranscriptomic Regulation, Genome Institute of Singapore, Singapore, 138672, Singapore. gmstanp@duke-nus.edu.sg. [22] SingHealth/Duke-NUS Institute of Precision Medicine, National Heart Centre Singapore, Singapore, 168752, Singapore. gmstanp@duke-nus.edu.sg. [23] Department of Physiology, National University of Singapore, Singapore, 117593, Singapore. gmstanp@duke-nus.edu.sg. [24] Singapore Gastric Cancer Consortium, Singapore, 119228, Singapore. gmstanp@duke-nus.edu.sg. [25]
DOI 10.1186/s13073-021-00970-3
PMID 34635154
发布时间 2024-04-03
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