Overexpression of DTL enhances cell motility and promotes tumor metastasis in cervical adenocarcinoma by inducing RAC1-JNK-FOXO1 axis.
作者:
主题词
腺癌(Adenocarcinoma);动物(Animals);细胞系, 肿瘤(Cell Line, Tumor);细胞运动(Cell Movement);减量调节(Down-Regulation);上皮-间质转化(Epithelial-Mesenchymal Transition);女(雌)性(Female);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);JNK丝裂原活化蛋白激酶类(JNK Mitogen-Activated Protein Kinases);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 裸(Mice, Nude);中年人(Middle Aged);肿瘤转移(Neoplasm Metastasis);核蛋白质类(Nuclear Proteins);磷酰化(Phosphorylation);增量调节(Up-Regulation);宫颈肿瘤(Uterine Cervical Neoplasms);伤口愈合(Wound Healing);rac1 GTP结合蛋白质(rac1 GTP-Binding Protein);小鼠(Mice)
DOI
10.1038/s41419-021-04179-5
PMID
34635635
发布时间
2024-02-26
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