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Comparative Analysis of Genome Editors Efficiency on a Model of Mice Zygotes Microinjection.

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第一作者： Olga A,Averina

第一单位： Institute of Functional Genomics, Lomonosov Moscow State University, 119991 Moscow, Russia.;Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119899 Moscow, Russia.

作者： Olga A,Averina ^[1] ; Oleg A,Permyakov ^[2] ; Olga O,Grigorieva ^[2] ; Alexey S,Starshin ^[3] ; Alexander M,Mazur ^[3] ; Egor B,Prokhortchouk ^[3] ; Olga A,Dontsova ^[4] ; Petr V,Sergiev ^[5]

作者单位： Institute of Functional Genomics, Lomonosov Moscow State University, 119991 Moscow, Russia.;Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119899 Moscow, Russia. ^[1] Institute of Functional Genomics, Lomonosov Moscow State University, 119991 Moscow, Russia. ^[2] Research Center of Biotechnology of the Russian Academy of Sciences, Institute of Bioengineering, 119071 Moscow, Russia. ^[3] Department of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia.;Center of Life Sciences, Skolkovo Institute of Science and Technology, 121205 Moscow, Russia.;Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 117997 Moscow, Russia. ^[4] Institute of Functional Genomics, Lomonosov Moscow State University, 119991 Moscow, Russia.;Department of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia.;Center of Life Sciences, Skolkovo Institute of Science and Technology, 121205 Moscow, Russia. ^[5]

关键词 CRISPR Cas9 genome editing homologous recombination knockout mice microinjection prime editor

医学主题词动物(Animals);DNA, 单链(DNA, Single-Stranded);小鼠(Mice);微量注射(Microinjections);模型, 动物(Models, Animal);合子(Zygote)

DOI 10.3390/ijms221910221

PMID 34638562

发布时间 2024-01-04

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