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首页> International journal of molecular sciences> Reduced Endothelial Leptin Signaling Increases Vascular Adrenergic Reactivity in a Mouse Model of Congenital Generalized Lipodystrophy.

Reduced Endothelial Leptin Signaling Increases Vascular Adrenergic Reactivity in a Mouse Model of Congenital Generalized Lipodystrophy.

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作者： Thiago,Bruder-Nascimento ^[1] ; Taylor C,Kress ^[2] ; Matthew,Pearson ^[3] ; Weiqin,Chen ^[1] ; Simone,Kennard ^[1] ; Eric J,Belin de Chantemèle ^[4]

作者单位： Vascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA. ^[1] Department of Pediatrics, Division of Endocrinology, Center for Pediatric Research in Obesity and Metabolism (CPROM), University of Pittsburgh, Pittsburgh, PA 15260, USA. ^[2] Vascular Medicine Institute (VMI), University of Pittsburgh, Pittsburgh, PA 15260, USA. ^[3] Department of Physiology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA. ^[4] Department of Medicine, Division of Cardiology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA. ^[5]

关键词 adipose tissue leptin lipodystrophy vascular function

主题词肾上腺素能药(Adrenergic Agents);动物(Animals);主动脉, 胸(Aorta, Thoracic);疾病模型, 动物(Disease Models, Animal);内皮, 血管(Endothelium, Vascular);GTP结合蛋白质γ亚单位(GTP-Binding Protein gamma Subunits);瘦素(Leptin);脂质营养不良, 先天性全身性(Lipodystrophy, Congenital Generalized);男(雄)性(Male);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);肌收缩(Muscle Contraction);肌, 平滑, 血管(Muscle, Smooth, Vascular);一氧化氮合酶Ⅰ型(Nitric Oxide Synthase Type I);受体, 瘦素(Receptors, Leptin);信号传导(Signal Transduction);治疗结果(Treatment Outcome)

DOI 10.3390/ijms221910596

PMID 34638939

发布时间 2021-11-08

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International journal of molecular sciences

International journal of molecular sciences

2021年22卷19期

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