Complex Positive Effects of SGLT-2 Inhibitor Empagliflozin in the Liver, Kidney and Adipose Tissue of Hereditary Hypertriglyceridemic Rats: Possible Contribution of Attenuation of Cell Senescence and Oxidative Stress.-论文-万方医学网

第一作者： Jaroslava,Trnovska

第一单位： Cardiometabolic Research Division, Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic.

作者： Jaroslava,Trnovska ^[1] ; Petr,Svoboda ^[2] ; Helena,Pelantova ^[3] ; Marek,Kuzma ^[4] ; Helena,Kratochvilova ^[1] ; Barbora Judita,Kasperova ^[5] ; Iveta,Dvorakova ^[1] ; Katerina,Rosolova ^[6] ; Hana,Malinska ^[1] ; Martina,Huttl ^[1] ; Irena,Markova ^[1] ; Olena,Oliyarnyk ^[1] ; Magdalena,Melcova ^[7] ; Vojtech,Skop ^[2] ; Milos,Mraz ^[5] ; Sona,Stemberkova-Hubackova ^[8] ; Martin,Haluzik ^[9]

作者单位： Cardiometabolic Research Division, Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic. ^[1] Cardiometabolic Research Division, Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic.;Laboratory of Animal Biochemistry, Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, 166 28 Prague, Czech Republic. ^[2] Laboratory of Molecular Structure Characterization, Institute of Microbiology, Czech Academy of Sciences, 142 20 Prague, Czech Republic. ^[3] Laboratory of Molecular Structure Characterization, Institute of Microbiology, Czech Academy of Sciences, 142 20 Prague, Czech Republic.;Department of Analytical Chemistry, Faculty of Science, Palacky University Olomouc, 779 00 Olomouc, Czech Republic. ^[4] Diabetes Centre, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic. ^[5] Laboratory of Animal Biochemistry, Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, 166 28 Prague, Czech Republic.;Diabetes Centre, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic. ^[6] Laboratory of Animal Biochemistry, Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, 166 28 Prague, Czech Republic. ^[7] Laboratory of Molecular Therapy, Institute of Biotechnology, Czech Academy of Sciences, 252 50 Prague, Czech Republic. ^[8] Diabetes Centre, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic.;Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital, 128 08 Prague, Czech Republic. ^[9]

主题词 3T3-L1细胞(3T3-L1 Cells);脂肪组织(Adipose Tissue);投药, 口服(Administration, Oral);动物(Animals);二苯甲基化合物(Benzhydryl Compounds);细胞存活(Cell Survival);疾病模型, 动物(Disease Models, Animal);减量调节(Down-Regulation);血脂异常(Dyslipidemias);糖原异生(Gluconeogenesis);葡糖苷类(Glucosides);Hep G2细胞(Hep G2 Cells);人类(Humans);高甘油三酯血症(Hypertriglyceridemia);降血糖药(Hypoglycemic Agents);胰岛素抗药性(Insulin Resistance);肾(Kidney);脂肪生成(Lipogenesis);肝(Liver);男(雄)性(Male);小鼠(Mice);氧化性应激(Oxidative Stress);大鼠(Rats);治疗结果(Treatment Outcome);增量调节(Up-Regulation);体重增长(Weight Gain)

DOI 10.3390/ijms221910606

PMID 34638943

发布时间 2021-11-08

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Complex Positive Effects of SGLT-2 Inhibitor Empagliflozin in the Liver, Kidney and Adipose Tissue of Hereditary Hypertriglyceridemic Rats: Possible Contribution of Attenuation of Cell Senescence and Oxidative Stress.

International journal of molecular sciences

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International journal of molecular sciences

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Complex Positive Effects of SGLT-2 Inhibitor Empagliflozin in the Liver, Kidney and Adipose Tissue of Hereditary Hypertriglyceridemic Rats: Possible Contribution of Attenuation of Cell Senescence and Oxidative Stress.

International journal of molecular sciences

相似文献

International journal of molecular sciences

相关期刊

检索历史清除