Four-dimensional chromosome reconstruction elucidates the spatiotemporal reorganization of the mammalian X chromosome.

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第一作者： Anna,Lappala

第一单位： Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545.

作者： Anna,Lappala ^[1] ; Chen-Yu,Wang ^[2] ; Andrea,Kriz ^[3] ; Hunter,Michalk ^[2] ; Kevin,Tan ^[3] ; Jeannie T,Lee ^[2] ; Karissa Y,Sanbonmatsu ^[3]

作者单位： Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545. ^[1] Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114. ^[2] Department of Genetics, The Blavatnik Institute, Harvard Medical School, Boston, MA 02114. ^[3] Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114; lee@molbio.mgh.harvard.edu kys@lanl.gov. ^[4] Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545; lee@molbio.mgh.harvard.edu kys@lanl.gov. ^[5] New Mexico Consortium, Los Alamos, NM 87545. ^[6]

关键词 3D modeling SMCHD1 X chromosome inactivation Xist RNA chromosome structure

主题词动物(Animals);哺乳动物(Mammals);X染色体(X Chromosome);X染色体失活(X Chromosome Inactivation)

DOI 10.1073/pnas.2107092118

PMID 34645712

发布时间 2022-04-14

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