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VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody.

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第一作者： Laura,Micheli

第一单位： Department of Neuroscience, Psychology, Drug Research and Child Health - NEUROFARBA - Pharmacology and Toxicology Section, University of Florence, Viale G. Pieraccini 6, 50139, Florence, Italy.

作者： Laura,Micheli ^[1] ; Carmen,Parisio ^[1] ; Elena,Lucarini ^[1] ; Alessia,Vona ^[1] ; Alessandra,Toti ^[1] ; Alessandra,Pacini ^[2] ; Tommaso,Mello ^[3] ; Serena,Boccella ^[4] ; Flavia,Ricciardi ^[4] ; Sabatino,Maione ^[5] ; Grazia,Graziani ^[6] ; Pedro Miguel,Lacal ^[7] ; Paola,Failli ^[1] ; Carla,Ghelardini ^[1] ; Lorenzo,Di Cesare Mannelli ^[8]

作者单位： Department of Neuroscience, Psychology, Drug Research and Child Health - NEUROFARBA - Pharmacology and Toxicology Section, University of Florence, Viale G. Pieraccini 6, 50139, Florence, Italy. ^[1] Department of Experimental and Clinical Medicine - DMSC - Anatomy and Histology Section, University of Florence, L.go Brambilla 3, 50134, Florence, Italy. ^[2] Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Viale G. Pieraccini 6, 50139, Florence, Italy. ^[3] Department of Experimental Medicine, Section of Pharmacology, University of Campania "L. Vanvitelli", Via Santa Maria di Costantinopoli 16, 80138, Naples, Italy. ^[4] Department of Experimental Medicine, Section of Pharmacology, University of Campania "L. Vanvitelli", Via Santa Maria di Costantinopoli 16, 80138, Naples, Italy.;I.R.C.S.S., Neuromed, 86077, Pozzilli, Italy. ^[5] Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133, Rome, Italy. graziani@uniroma2.it.;IDI-IRCCS, Via Monti di Creta 104, 00167, Rome, Italy. graziani@uniroma2.it. ^[6] IDI-IRCCS, Via Monti di Creta 104, 00167, Rome, Italy. ^[7] Department of Neuroscience, Psychology, Drug Research and Child Health - NEUROFARBA - Pharmacology and Toxicology Section, University of Florence, Viale G. Pieraccini 6, 50139, Florence, Italy. lorenzo.mannelli@unifi.it. ^[8]

关键词 Astrocytes D16F7 mAb Melanoma Neuropathy biomarker Oxaliplatin Paclitaxel VEGF-A VEGFR-1 Vincristine

医学主题词动物(Animals);抗体, 单克隆(Antibodies, Monoclonal);人类(Humans);男(雄)性(Male);小鼠(Mice);神经痛(Neuralgia);信号传导(Signal Transduction)

DOI 10.1186/s13046-021-02127-x

PMID 34649573

发布时间 2024-04-26

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准确一般字义偏差语意偏离译文作用小提交