Early assessment of circulating tumor DNA after curative-intent resection predicts tumor recurrence in early-stage and locally advanced non-small-cell lung cancer.

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作者： Silvia,Waldeck ^[1] ; Jan,Mitschke ^[2] ; Sebastian,Wiesemann ^[1] ; Michael,Rassner ^[3] ; Geoffroy,Andrieux ^[1] ; Max,Deuter ^[2] ; Jurik,Mutter ^[4] ; Anne-Marie,Lüchtenborg ^[1] ; Daniel,Kottmann ^[1] ; Laurin,Titze ^[5] ; Christoph,Zeisel ^[1] ; Martina,Jolic ^[3] ; Ulrike,Philipp ^[3] ; Silke,Lassmann ^[1] ; Peter,Bronsert ^[1] ; Christine,Greil ^[2] ; Justyna,Rawluk ^[5] ; Heiko,Becker ^[5] ; Lisa,Isbell ^[1] ; Alexandra,Müller ^[1] ; Soroush,Doostkam ^[1] ; Bernward,Passlick ^[1] ; Melanie,Börries ^[6] ; Justus,Duyster ^[6] ; Julius,Wehrle ^[3] ; Florian,Scherer ^[2] ; Nikolas,von Bubnoff ^[4]

作者单位： Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. ^[1] German Cancer Consortium (DKTK), Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany. ^[2] Department of Thoracic Surgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. ^[3] Institute of Medical Bioinformatics and Systems Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. ^[4] Institute for Surgical Pathology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. ^[5] Institute for Neuropathology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. ^[6] Department of Hematology and Oncology, University Hospital Schleswig-Holstein, Lübeck, Germany. ^[7]

关键词 circulating tumor DNA early-stage and locally advanced non-small-cell lung cancer minimal residual disease noninvasive biomarker relapse prediction