Active Targeting Significantly Outperforms Nanoparticle Size in Facilitating Tumor-Specific Uptake in Orthotopic Pancreatic Cancer.

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第一作者： William M,MacCuaig

第一单位： Stephenson Cancer Center, University of Oklahoma, Oklahoma City, Oklahoma 73104, United States.;Department of Biomedical Engineering, University of Oklahoma, Norman, Oklahoma 73019, United States.

作者： William M,MacCuaig ^[1] ; Benjamin L,Fouts ^[2] ; Molly W,McNally ^[3] ; William E,Grizzle ^[4] ; Phillip,Chuong ^[5] ; Abhilash,Samykutty ^[6] ; Priyabrata,Mukherjee ^[2] ; Min,Li ^[2] ; Jacek B,Jasinski ^[7] ; Bahareh,Behkam ^[8] ; Lacey R,McNally ^[9]

作者单位： Stephenson Cancer Center, University of Oklahoma, Oklahoma City, Oklahoma 73104, United States.;Department of Biomedical Engineering, University of Oklahoma, Norman, Oklahoma 73019, United States. ^[1] Stephenson Cancer Center, University of Oklahoma, Oklahoma City, Oklahoma 73104, United States. ^[2] Department of Surgery, University of Oklahoma, Oklahoma City, Oklahoma 73104, United States.;Department of Cancer Biology, Wake Forest University, Winston-Salem, North Carolina 27157, United States. ^[3] Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States. ^[4] Department of Surgery, University of Louisville, Louisville, Kentucky 40202, United States. ^[5] Stephenson Cancer Center, University of Oklahoma, Oklahoma City, Oklahoma 73104, United States.;Department of Biomedical Engineering, University of Oklahoma, Norman, Oklahoma 73019, United States.;Department of Cancer Biology, Wake Forest University, Winston-Salem, North Carolina 27157, United States. ^[6] Conn Center Materials Characterization, University of Louisville, Louisville, Kentucky 40202, United States. ^[7] Department of Mechanical Engineering, Virginia Tech, Blacksburg, Virginia 24061, United States. ^[8] Stephenson Cancer Center, University of Oklahoma, Oklahoma City, Oklahoma 73104, United States.;Department of Surgery, University of Oklahoma, Oklahoma City, Oklahoma 73104, United States.;Department of Biomedical Engineering, University of Oklahoma, Norman, Oklahoma 73019, United States.;Department of Cancer Biology, Wake Forest University, Winston-Salem, North Carolina 27157, United States. ^[9]

关键词 actively targeted nanoparticles mesoporous silica nanoparticles nanoparticle size pancreatic cancer tumor specificity