首页> Clinical infectious diseases : an official publication of the Infectious Diseases Society of America> Optimizing Dosing and Fixed-Dose Combinations of Rifampicin, Isoniazid, and Pyrazinamide in Pediatric Patients With Tuberculosis: A Prospective Population Pharmacokinetic Study.

Optimizing Dosing and Fixed-Dose Combinations of Rifampicin, Isoniazid, and Pyrazinamide in Pediatric Patients With Tuberculosis: A Prospective Population Pharmacokinetic Study.

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第一作者： Paolo,Denti

第一单位： Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

作者： Paolo,Denti ^[1] ; Roeland E,Wasmann ^[1] ; Annelies,van Rie ^[2] ; Jana,Winckler ^[3] ; Adrie,Bekker ^[3] ; Helena,Rabie ^[4] ; Anneke C,Hesseling ^[3] ; Louvina E,van der Laan ^[5] ; Carmen,Gonzalez-Martinez ^[6] ; Heather J,Zar ^[7] ; Gerry,Davies ^[8] ; Lubbe,Wiesner ^[1] ; Elin M,Svensson ^[9] ; Helen M,McIlleron ^[10]

作者单位： Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa. ^[1] Family Medicine and Population Health, Faculty of Medicine, University of Antwerp, Antwerp, Belgium. ^[2] Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. ^[3] Department of Paediatrics and Child Health and FAMily Centre for Research with Ubuntu (FAMCRU) Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa. ^[4] Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.;Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. ^[5] Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi/Liverpool School of Tropical Medicine. ^[6] Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, and SA-MRC Unit on Child & Adolescent Health, University of Cape Town, Cape Town, South Africa. ^[7] Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.;Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom. ^[8] Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.;Department of Pharmacy, Uppsala University, Uppsala, Sweden. ^[9] Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.;Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa. ^[10]

关键词 NONMEM children first-line tuberculosis treatment fixed-dose combination pharmacokinetics