Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF.

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第一作者： Martin L,Decaris

第一单位： Pliant Therapeutics, South San Francisco, CA, USA.

作者： Martin L,Decaris ^[1] ; Johanna R,Schaub ^[1] ; Chun,Chen ^[1] ; Jacob,Cha ^[1] ; Gail G,Lee ^[1] ; Megi,Rexhepaj ^[1] ; Steve S,Ho ^[1] ; Vikram,Rao ^[1] ; Megan M,Marlow ^[1] ; Prerna,Kotak ^[1] ; Erine H,Budi ^[1] ; Lisa,Hooi ^[1] ; Jianfeng,Wu ^[1] ; Marina,Fridlib ^[1] ; Shamra P,Martin ^[1] ; Shaoyi,Huang ^[1] ; Ming,Chen ^[1] ; Manuel,Muñoz ^[1] ; Timothy F,Hom ^[1] ; Paul J,Wolters ^[2] ; Tushar J,Desai ^[3] ; Fernando,Rock ^[1] ; Katerina,Leftheris ^[1] ; David J,Morgans ^[4] ; Eve-Irene,Lepist ^[1] ; Patrick,Andre ^[5] ; Eric A,Lefebvre ^[1] ; Scott M,Turner ^[6]

作者单位： Pliant Therapeutics, South San Francisco, CA, USA. ^[1] Department of Medicine, University of California, San Francisco, CA, USA. ^[2] Department of Medicine, Stanford University, Stanford, CA, USA. ^[3] Pliant Therapeutics, South San Francisco, CA, USA.;Maze Therapeutics, South San Francisco, CA, USA. ^[4] Pliant Therapeutics, South San Francisco, CA, USA.;Acceleron Pharma, Cambridge, MA, USA. ^[5] Pliant Therapeutics, South San Francisco, CA, USA. sturner@pliantrx.com. ^[6]

关键词 Antifibrotic PLN-74809 Precision-cut lung slice Transforming growth factor-β αv integrin