The intraviral protein-protein interaction of SARS-CoV-2 reveals the key role of N protein in virus-like particle assembly.

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作者： Minghai,Chen ^[1] ; Chuang,Yan ^[1] ; Fujun,Qin ^[1] ; Luping,Zheng ^[1] ; Xian-En,Zhang ^[2]

作者单位： CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China. ^[1] Faculty of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China. ^[2] National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. ^[3]

关键词 BiFC SARS-CoV-2 VLPs interactome nucleocapsid protein

主题词 HEK293细胞(HEK293 Cells);人类(Humans);磷蛋白类(Phosphoproteins);病毒装配(Virus Assembly)

DOI 10.7150/ijbs.64977

PMID 34671206

发布时间 2022-03-09

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