In Vitro Simulation of the Environment in the Upper Gastrointestinal Lumen After Drug Administration in the Fed State Using the TIM-1 System and Comparison With Luminal Data in Adults.

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作者： Christina,Pentafragka ^[1] ; Irena,Tomaszewska ^[2] ; Susann,Bellmann ^[3] ; Mans,Minekus ^[3] ; Ronald,Schilderink ^[3] ; Maria,Vertzoni ^[1] ; Mark,McAllister ^[2] ; Christos,Reppas ^[4]

作者单位： Department of Pharmacy, National and Kapodistrian University of Athens, Zografou, Greece. ^[1] Pfizer Drug Product Design, Sandwich, UK. ^[2] The TIM Company, Zeist, the Netherlands. ^[3] Department of Pharmacy, National and Kapodistrian University of Athens, Zografou, Greece. Electronic address: reppas@pharm.uoa.gr. ^[4]

关键词 Bile acids Danazol Fed state In vitro-in vivo relationships Paracetamol TIM-1 system pH

主题词成年人(Adult);计算机模拟(Computer Simulation);十二指肠(Duodenum);人类(Humans);小肠(Intestine, Small);胃(Stomach);悬液(Suspensions)

DOI 10.1016/j.xphs.2021.10.010

PMID 34673096

发布时间 2022-03-16

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