Antibody drug conjugates in gastrointestinal cancer: From lab to clinical development.

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第一作者： Davinder,Singh

第一单位： Natural Products and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.

作者： Davinder,Singh ^[1] ; Divya,Dheer ^[1] ; Abhilash,Samykutty ^[2] ; Ravi,Shankar ^[3]

作者单位： Natural Products and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. ^[1] Stephenson Comprehensive Cancer Center, University of Oklahoma, Oklahoma City, OK 73104, USA. Electronic address: Abhilash.Samykutty-1@ou.edu. ^[2] Natural Products and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address: rshankar@iiim.ac.in. ^[3]

关键词 Antibody-drug conjugate (ADC)Bioconjugation Cleavable and non-cleavable linkers Drug antibody ratio (DAR)Gastrointestinal malignancies Monoclonal antibodies Site-specific conjugation

主题词抗肿瘤药(Antineoplastic Agents);胃肠肿瘤(Gastrointestinal Neoplasms);人类(Humans);免疫轭合物(Immunoconjugates)

DOI 10.1016/j.jconrel.2021.10.006

PMID 34673122

发布时间 2021-12-24

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准确一般字义偏差语意偏离译文作用小提交