CRISPR activation of endogenous genes reprograms fibroblasts into cardiovascular progenitor cells for myocardial infarction therapy.

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作者： Lin,Jiang ^[1] ; Jialiang,Liang ^[2] ; Wei,Huang ^[1] ; Jianyong,Ma ^[3] ; Ki Ho,Park ^[4] ; Zhichao,Wu ^[1] ; Peng,Chen ^[4] ; Hua,Zhu ^[4] ; Jian-Jie,Ma ^[4] ; Wenfeng,Cai ^[1] ; Christian,Paul ^[1] ; Liang,Niu ^[5] ; Guo-Chang,Fan ^[3] ; Hong-Sheng,Wang ^[3] ; Onur,Kanisicak ^[1] ; Meifeng,Xu ^[1] ; Yigang,Wang ^[6]

作者单位： Department of Pathology and Laboratory Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA. ^[1] Department of Pathology and Laboratory Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA. Electronic address: liangjl@ucmail.uc.edu. ^[2] Department of Pharmacology and Systems Physiology, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA. ^[3] Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA. ^[4] Division of Biostatistics and Bioinformatics, Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA. ^[5] Department of Pathology and Laboratory Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA. Electronic address: yi-gang.wang@uc.edu. ^[6]

关键词 CRISPR cardiovascular progenitor cells cell reprogramming heart regeneration myocardial infarction

主题词动物(Animals);细胞分化(Cell Differentiation);成纤维细胞(Fibroblasts);小鼠(Mice);心肌梗死(Myocardial Infarction);肌细胞, 心脏(Myocytes, Cardiac);干细胞(Stem Cells)

DOI 10.1016/j.ymthe.2021.10.015

PMID 34678511

发布时间 2024-09-23

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