Protocatechuic Acid, a Simple Plant Secondary Metabolite, Induced Apoptosis by Promoting Oxidative Stress through HO-1 Downregulation and p21 Upregulation in Colon Cancer Cells.

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作者： Rosaria,Acquaviva ^[1] ; Barbara,Tomasello ^[1] ; Claudia,Di Giacomo ^[1] ; Rosa,Santangelo ^[1] ; Alfonsina,La Mantia ^[1] ; Irina,Naletova ^[2] ; Maria Grazia,Sarpietro ^[1] ; Francesco,Castelli ^[1] ; Giuseppe Antonio,Malfa ^[1]

作者单位： Department of Drug and Health Science, University of Catania, Viale A. Doria 6, 95125 Catania, Italy. ^[1] Institute of Crystallography, National Research Council (CNR), Via Paolo Gaifami, 18, 95126 Catania, Italy. ^[2]

关键词 CaCo-2 LDH leakage annexin V p21 phenolic acids prooxidants total thiol groups γ-GCS

主题词细胞凋亡(Apoptosis);Caco-2细胞(Caco-2 Cells);细胞死亡(Cell Death);细胞存活(Cell Survival);结肠肿瘤(Colonic Neoplasms);周期素依赖激酶抑制剂p21(Cyclin-Dependent Kinase Inhibitor p21);减量调节(Down-Regulation);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);谷氨酸-半胱氨酸连接酶(Glutamate-Cysteine Ligase);血红素加氧酶-1(Heme Oxygenase-1);人类(Humans);L-乳酸脱氢酶(L-Lactate Dehydrogenase);氧化还原(Oxidation-Reduction);氧化性应激(Oxidative Stress);植物(Plants);活性氧(Reactive Oxygen Species);巯基化合物(Sulfhydryl Compounds);增量调节(Up-Regulation)

DOI 10.3390/biom11101485

PMID 34680118

发布时间 2022-01-12

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Biomolecules

2021年11卷10期

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Protocatechuic Acid, a Simple Plant Secondary Metabolite, Induced Apoptosis by Promoting Oxidative Stress through HO-1 Downregulation and p21 Upregulation in Colon Cancer Cells.

Biomolecules

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Protocatechuic Acid, a Simple Plant Secondary Metabolite, Induced Apoptosis by Promoting Oxidative Stress through HO-1 Downregulation and p21 Upregulation in Colon Cancer Cells.

Biomolecules

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Biomolecules

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